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Emerging roles of podoplanin in vascular development and homeostasis
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《医学前沿(英文)》 2015年 第9卷 第4期 页码 421-430 doi: 10.1007/s11684-015-0424-9
Podoplanin (PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Prox1 and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.
关键词: podoplanin CLEC-2 Prox1 O-glycosylation lymphatic vascular development and maintenance lymphoid organ homeostasis
Development and application of an off-site maintenance system in the petrochemical industry
Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING
《工程管理前沿(英文)》 2017年 第4卷 第2期 页码 111-126 doi: 10.15302/J-FEM-2017027
关键词: on-site maintenance petrochemical industry safety off-site maintenance system
张海军,左洪福,梁剑,戎翔
《中国工程科学》 2005年 第7卷 第11期 页码 17-20
目前视情维修是民航业采用的主要维修方式,可以使维修的有效性、经济性大幅度提高。维修决策优化模型对民航维修成本的降低和利润的提升具有显著的指导作用;归纳了视情维修的时间延迟模型、冲击模型、比例危险模型、马尔可夫决策模型等优化模型的建模方法;分析了该类模型在应用中存在的不足,并展望了其发展前景。
Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
《医学前沿(英文)》 2009年 第3卷 第2期 页码 164-170 doi: 10.1007/s11684-009-0038-1
关键词: epithelial-mesenchymal transition vascular endothelial cell growth factor matrix metalloproteinase-9 cyclooxygenase-2 higher microvascular density breast cancer
Endostatin specifically targets both tumor blood vessels and lymphatic vessels
Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo
《医学前沿(英文)》 2011年 第5卷 第4期 页码 336-340 doi: 10.1007/s11684-011-0163-5
关键词: endostatin angiogenesis lymphangiogenesis nystatin internalization tumor
《工程管理前沿(英文)》 doi: 10.1007/s42524-023-0282-0
关键词: risk evaluation maintenance steering group analytic network process task transfer maintenance program
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 177-180 doi: 10.1007/s11684-009-0021-x
关键词: vascular endothelial growth factors restenosis reactive oxygen species endothelial cells vascular smooth muscle cell
Human reliability in maintenance task
Pacaiova HANA,
《机械工程前沿(英文)》 2010年 第5卷 第2期 页码 184-188 doi: 10.1007/s11465-010-0002-4
关键词: maintenance risk assessment failure reliability prevention
Crk-associated substrate, vascular smooth muscle and hypertension
TANG Dale
《医学前沿(英文)》 2008年 第2卷 第4期 页码 323-331 doi: 10.1007/s11684-008-0062-6
关键词: Contraction stimulation phosphatase-proline molecular structure discovered hypertension
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 284-286 doi: 10.1007/s11684-009-0062-1
关键词: vascular endothelial growth factor nitric oxide N-nitro-L-arginine methyl ester vascular endothelial cells
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 67-78 doi: 10.1007/s11684-012-0176-8
Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.
关键词: angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 320-329 doi: 10.1007/s11684-016-0463-x
Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients. p-Cresyl sulfate (PCS) is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE−/− mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group (n = 20) and PCS-treated group (n = 20). Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells (VSMCs) were treated with phosphate buffer solution or 500 µmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.
关键词: p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 403-409 doi: 10.1007/s11684-017-0522-y
Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.
关键词: arterial thrombosis conditional knockout mice tissue factor pathway inhibitor vascular smooth muscle cells
A review of condition-based maintenance: Its prognostic and operational aspects
Yanrong LI, Shizhe PENG, Yanting LI, Wei JIANG
《工程管理前沿(英文)》 2020年 第7卷 第3期 页码 323-334 doi: 10.1007/s42524-020-0121-5
关键词: condition-based maintenance prognostics operational decision-making reliability
Trend prediction technology of condition maintenance for large water injection units
Xiaoli XU, Sanpeng DENG
《机械工程前沿(英文)》 2010年 第5卷 第2期 页码 171-175 doi: 10.1007/s11465-009-0091-0
关键词: water injection units condition-based maintenance trend prediction
标题 作者 时间 类型 操作
Development and application of an off-site maintenance system in the petrochemical industry
Ruisheng YONG, Yanbing YE, Hanbin LUO, Lieyun DING
期刊论文
Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP
Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
期刊论文
Endostatin specifically targets both tumor blood vessels and lymphatic vessels
Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo
期刊论文
Risk evaluation for the task transfer of an aircraft maintenance program based on a multielement connection
期刊论文
Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty
Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU
期刊论文
Role of nitric oxide in biological effects of vascular endothelial growth factor
Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,
期刊论文
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
期刊论文
sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by targeting vascular
null
期刊论文
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis
null
期刊论文
A review of condition-based maintenance: Its prognostic and operational aspects
Yanrong LI, Shizhe PENG, Yanting LI, Wei JIANG
期刊论文